闫洁熙
【基本情况】
闫洁熙,副研究员,兰大一院精准医学实验室副主任,兰大一院实验诊断学教研室副主任,学术型硕士研究生导师。
【学习经历】
2003.9—2007.07 4556银河国际app生命科学学院,学士
2007.9—2013.07 4556银河国际app生命科学学院,硕博连读
【工作经历】
2014.09— 2018.08 4556银河国际app第一医院,中心实验室,助理研究员
2018.10— 2020.12 4556银河国际app第一医院,科研与发展规划处,助理研究员
2021.01— 至今 4556银河国际app第一医院,精准医学实验室,副研究员
【主要科研成果】
研究方向:
1 基因组学与分子诊断
2 肽类靶向药物的设计及应用
主持或参与科研项目:
1 国家自然科学基金,新结构环肽抗生素Lugdunin衍生物的设计、合成及抗菌活性和作用机制研究, 2023/01至2026/12,33万元,在研,主持;
2 甘肃省陇原青年创新创业人才项目,早期肝癌患者cfDNA多基因甲基化检测模型的构建,2023/05-2024/04,20万元,在研,主持;
3 甘肃省自然科学基金,革兰氏阴性菌特异性靶向抗菌肽的设计、合成及筛选,2022/01至2024/12,6万元,在研,主持;
4 甘肃省自然科学基金,具有杀精活性的抗微生物多肽LL-37类似物的设计及筛选,2020/01至2022/12,3万元,结题,主持;
5 甘肃省自然科学基金,新型抗微生物多肽治疗医用材料相关性生物被膜感染的临床前基础研究,2017/01至2019/12,4万元,结题,主持;
6 国家自然科学基金,脂肪酸代谢相关基因的甲基化调控在卵巢储备下降发生过程中的机制研究,2020/01至2023/12,35万,结题,参与;
发表主要论文或专著:
1. Xiaolei Liang(#),Jiexi Yan(#),Yingwei Lu,Shan Liu,Xiaojing Chai(*),The Antimicrobial Peptide Melectin Shows Both Antimicrobial and Antitumor Activity via Membrane Interference and DNA Binding,Drug Des Devel Ther. 2021 Mar 19;15:1261-1273
2. Xiaolei Liang,Ruirui Wang, Wenshan Dou, Li Zhao, Lanxia Zhou, Junfang Zhu, Kairong Wang, Jiexi Yan(*),Arminin 1a-C, a novel antimicrobial peptide from ancient metazoan Hydra, shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells,Drug Des Devel Ther. 2018;12:3691-3703.
3. Jiexi Yan(#); Xiaolei Liang(#); Caijuan Bai; Lanxia Zhou; Juan Li; Kairong Wang; Yan Tang; Li Zhao(*), NK-18, a promising antimicrobial peptide: anti-multidrug resistant leukemia cells and LPS neutralizing properties, Biochimie, 2018.02.07, 147: 143~152
4. Jiexi Yan(#),Xiaolei Liang(#),Chang Liu,Yuemei Cheng,Lanxia Zhou,Kairong Wang,Li Zhao(*),Influence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2,Probiotics Antimicrob Proteins,2018,(10): 118-127
5. Kairong Wang(#),Jiexi Yan(#),Wen Dang,Junqiu Xie,Bo Yan,Wenjin Yan,Mengyang Sun,Bangzhi Zhang,Mingxia Ma,Yanyan Zhao,Fengjing Jia,Ranran Zhu,Wei Chen,Rui Wang(*),Dual antifungal properties of cationic antimicrobial peptides polybia-MPI: Membrane integrity disruption and inhibition of biofilm formation,Peptides,2014.6.01,56:22~29
6. Jiexi Yan(#),Kairong Wang(#),Wen Dang,Ru Chen,Junqiu Xie,Bangzhi Zhang,Jingjing Song,Rui Wang(*),Two hits are better than one: membrane-active and DNA binding-related double-action mechanism of NK-18, a novel antimicrobial peptide derived from mammalian NK-lysin.,Antimicrob Agents Chemother,2013.1.01,57(1):220~228
7. Kairong Wang(#),Jiexi Yan(#),Wen Dang,Xin Liu,Ru Chen,Jindao Zhang,Bangzhi Zhang,Wei Zhang,Ming Kai,Wenjin Yan,Zhibin Yang,Junqiu Xie,Rui Wang(*),Membrane active antimicrobial activity and molecular dynamics study of a novel cationic antimicrobial peptide polybia-MPI, from the venom of Polybia paulista,Peptides,2013.1.01,39:80~88
8. Jiexi Yan(#),Kairong Wang(#),Ru Chen,Jingjing Song,Bangzhi Zhang,Wen Dang,Wei Zhang,Rui Wang(*),Membrane active antitumor activity of NK-18, a mammalian NK-lysin-derived cationic antimicrobial peptide,Biochimie,2012.1.01,94(1):184~191
9. Kairong Wang(#),Jiexi Yan(#),Ru Chen,Wen Dang,Bangzhi Zhang,Wei Zhang,Jingjing Song,Rui Wang(*),Membrane-active action mode of polybia-CP, a novel antimicrobial peptide isolated from the venom of Polybia paulista.,Antimicrob Agents Chemother,2012.6.01,56(6):3318~3323
【社会兼职和社会服务】
甘肃省老年医学学会分子诊断医学专业委员会委员、中国老年学和老年医学学会肿瘤康复分会精准医疗专家委员会委员、中国医学装备协会基因检测分会委员
【联系方式】
办公电话:0931-8356018
E-mail:yanjx_1121@163.com